ABSTRACT
Objective • To investigate the relationship between body mass index (BMI) and central haemodynamic indices in physical examination population. Methods • From December 2017 to June 2018, a total of 287 subjects undergoing health examination (164 males, accounting for 57.1%) in the Physical Examination Center, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine were included. According to BMI, the subjects were divided into normal BMI group (BMI<24 kg/m2), overweight group (24 kg/m2 ≤ BMI<28 kg/m2), and obesity group (BMI ≥ 28 kg/m2). The peripheral systolic blood pressure (PSP), the peripheral diastolic blood pressure (PDP), the peripheral pulse pressure (PPP), and the mean arterial pressure (P-MAP) were measured, respectively. The central arterial pressures were measured by pulse wave analysis, including central systolic blood pressure (CSP), central diastolic blood pressure (CDP), central pulse pressure (CPP), central augmentation pressure (AP), and central augmentation index (AIx). The amplification index of pulse pressure was PPP/CPP. Results • ① The differences of PDP, CDP, P-MAP, AP, AIx and PPP/CPP among the three groups were statistically significant (P<0.05). ② Pearson correlation analysis showed that BMI was negatively correlated with AP and AIx (r=-0.140, r=-0.149, P<0.05), but positively correlated with PDP, CDP and PPP/CPP (r=0.151, r=0.155, r=0.124, P<0.05). ③ Multiple linear regression analysis showed that BMI was not an independent related factor for CSP. Conclusion • With the increase of BMI, AP and AIx show a downward trend, but PDP, CDP, and PPP/ CPP show an upward trend; BMI and CSP have no significant correlation.